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Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

✍ Scribed by Sherborne, Amy L; Hosking, Fay J; Prasad, Rashmi B; Kumar, Rajiv; Koehler, Rolf; Vijayakrishnan, Jayaram; Papaemmanuil, Elli; Bartram, Claus R; Stanulla, Martin; Schrappe, Martin


Book ID
109914607
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
375 KB
Volume
42
Category
Article
ISSN
1061-4036

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Deletion of the 9p21 chromosomal region is frequently found in childhood acute lymphoblastic leukemia (ALL). The target of these deletions is CDKN2A, a gene encoding both p16(INK4a) and p14(ARF). However, contiguous genes such as CDKN2B, encoding p15(INK4b), or MTAP, encoding methylthioadenosine pho