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FLT3 mutations in childhood acute lymphoblastic leukemia at first relapse

✍ Scribed by Wellmann, S; Moderegger, E; Zelmer, A; Bettkober, M; von Stackelberg, A; Henze, G; Seeger, K

Book ID: 110056178
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 60 KB
Volume: 19
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2403655

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## Abstract Casitas B‐lineage lymphoma (CBL) proteins are RING finger ubiquitin E3 ligases that attenuate the signaling of receptor tyrosine kinases and are mutated in a number of myeloid disorders. In this study, mutational screening of the linker‐RING domains of __CBL__ and __CBLB__ was performed