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Homozygous deletions at 9p21 in childhood acute lymphoblastic leukemia detected by microsatellite analysis

✍ Scribed by Takeuchi, S; Koike, M; Seriu, T; Bartram, C R; Slater, J; Park, S; Miyoshi, I; Koeffler, H P


Book ID
110053653
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
315 KB
Volume
11
Category
Article
ISSN
0887-6924

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Deletion of the 9p21 chromosomal region is frequently found in childhood acute lymphoblastic leukemia (ALL). The target of these deletions is CDKN2A, a gene encoding both p16(INK4a) and p14(ARF). However, contiguous genes such as CDKN2B, encoding p15(INK4b), or MTAP, encoding methylthioadenosine pho