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Variants of galactose-1-phosphate uridyl transferase in the Greek populations

✍ Scribed by A. Thomakos; E. Beutler; G. Stamatoyannopoulos

Publisher
Springer
Year
1977
Tongue
English
Weight
260 KB
Volume
36
Category
Article
ISSN
0340-6717

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✦ Synopsis

The frequency of variants of galactose-1-phosphate uridyl transferase was determined among the nine Greek populations by studying a sample of 1570 unselected individuals. Average frequency of normal allele GALT=0.942, galactosemia gen GALTG=0.0021 and the Duarte variant gene GALTD=0.0548 were observed. Frequency of galactosemia heterozygotes among Greeks was similar to that in other Caucasian populations, but the frequency of the Duarte variant was considerably higher. With the exception of two populations, one with low (Epirus) and one with high (Thrace) frequencies, the polymorphism of the Duarte variant displays very similar frequencies in the various Greek population groups.

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