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Variant Chinese hamster cells resistant to the proline analogl-azetidine 2-carboxylic acid

โœ Scribed by M. L. Hooper; B. Carritt; P. S. G. Goldfarb; C. Slack

Book ID
112558770
Publisher
Springer
Year
1977
Tongue
English
Weight
552 KB
Volume
3
Category
Article
ISSN
1572-9931

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Mutant cell lines resistant to azetidine
Mutant cell lines resistant to azetidine-2-carboxylic acid: Alterations in the synthesis of proline from glutamic acid
โœ Ronna F. Lodato; Robert J. Smith; David L. Valle; Kathleen Crane ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 674 KB

Two mutant Chinese hamster lung fibroblast lines have been isolated that are resistant to the the toxic proline analog L-azetidine-2-carboxylic acid. The line designated AZCA-1 has 30-fold elevated activity of pyrroline-5-carboxylate synthase and a large increase in the rate of proline production an