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Characterization of Resistance to the Proline Analog Azetidine Carboxylic Acid in a Nicotiana sylvestris Cell Line

โœ Scribed by Breiman, Adina; Vunsh, Ron; Galun, Esra

Book ID
122530787
Publisher
Elsevier
Year
1982
Weight
780 KB
Volume
105
Category
Article
ISSN
0044-328X

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Two mutant Chinese hamster lung fibroblast lines have been isolated that are resistant to the the toxic proline analog L-azetidine-2-carboxylic acid. The line designated AZCA-1 has 30-fold elevated activity of pyrroline-5-carboxylate synthase and a large increase in the rate of proline production an