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Isolation and characterization of a mutant Chinese hamster cell line resistant to the glutamine analog 6-diazo-5-oxo-l-norleucine

✍ Scribed by Elliot R. Kaufman


Book ID
112557748
Publisher
Springer
Year
1985
Tongue
English
Weight
681 KB
Volume
11
Category
Article
ISSN
1572-9931

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Uptake of glutamine antimetabolites 6-di
✍ Klaus R. Huber; Henry Rosenfeld; Joseph Roberts πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 French βš– 488 KB

The uptake system for 6-diazo-5-0x0-L-norleucine (DON) was studied in mouse P388 leukemia cells. The D O N transport system was found to resemble that of another glutamine antimetabolite, Acivicin, in its strong temperature dependence, utilization of the "L" transport system, inhibition by glutamine