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VAMP1 Mutation Causes Dominant Hereditary Spastic Ataxia in Newfoundland Families

✍ Scribed by Cynthia V. Bourassa; Inge A. Meijer; Nancy D. Merner; Kanwal K. Grewal; Mark G. Stefanelli; Kathleen Hodgkinson; Elizabeth J. Ives; William Pryse-Phillips; Mandar Jog; Kym Boycott; David A. Grimes; Sharan Goobie; Richard Leckey; Patrick A. Dion; Guy A. Rouleau


Book ID
119184361
Publisher
American Society of Human Genetics
Year
2012
Tongue
English
Weight
875 KB
Volume
91
Category
Article
ISSN
0002-9297

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## Communicated by Christine Van Broeckhoven Hereditary spastic paraplegia (HSP) is a neurodegenerative disease characterized by lower-limb spasticity, hyperreflexia, progressive spastic gait abnormalities, and an extensor-plantar response. It is genetically very heterogeneous, with 28 Human Genome