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NIPA1 Gene Mutations Cause Autosomal Dominant Hereditary Spastic Paraplegia (SPG6)

✍ Scribed by Shirley Rainier; Jing-Hua Chai; Debra Tokarz; Robert D. Nicholls; John K. Fink


Book ID
117854313
Publisher
American Society of Human Genetics
Year
2003
Tongue
English
Weight
274 KB
Volume
73
Category
Article
ISSN
0002-9297

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## Communicated by Christine Van Broeckhoven Hereditary spastic paraplegia (HSP) is a neurodegenerative disease characterized by lower-limb spasticity, hyperreflexia, progressive spastic gait abnormalities, and an extensor-plantar response. It is genetically very heterogeneous, with 28 Human Genome

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