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Hereditary spastic paraplegia caused by mutations in the SPG4 gene

✍ Scribed by Bürger, Joachim; Fonknechten, Nuria; Hoeltzenbein, Maria; Neumann, Luitgart; Bratanoff, Elfriede; Hazan, Jamilé; Reis, André

Book ID: 110025021
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 287 KB
Volume: 8
Category: Article
ISSN: 1018-4813
DOI: 10.1038/sj.ejhg.5200528

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Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia of the lower limbs. Autosomal dominant hereditary spastic paraplegia 4 linked to chromosome 2p (SPG4) is the most co