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Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and -independent apoptotic signaling pathways

✍ Scribed by Rika Kawagoe; Hiroyuki Kawagoe; Kimihiko Sano

Book ID: 108403209
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 374 KB
Volume: 26
Category: Article
ISSN: 0145-2126
DOI: 10.1016/s0145-2126(01)00151-5

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## Abstract Exogenous β~2~‐microglobulin (β~2~m) induces significant apoptosis in the CCRF‐HSB‐2 human lymphoblastic leukemia cell line as detected by DNA fragmentation, DAPI staining and annexin V binding assay. β~2~m treatment induced the release of cytochrome c and apoptosis‐inducing factor (AIF