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Ceramide induces apoptosis via caspase-dependent and caspase-independent pathways in mesenchymal stem cells derived from human adipose tissue

✍ Scribed by Ji Yeon Park; Moon Jung Kim; Yong Keun Kim; Jae Suk Woo

Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
439 KB
Volume
85
Category
Article
ISSN
0340-5761

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## Abstract Exogenous Ξ²~2~‐microglobulin (Ξ²~2~m) induces significant apoptosis in the CCRF‐HSB‐2 human lymphoblastic leukemia cell line as detected by DNA fragmentation, DAPI staining and annexin V binding assay. Ξ²~2~m treatment induced the release of cytochrome c and apoptosis‐inducing factor (AIF