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Valproic acid dosage and plasma protein binding and clearance

✍ Scribed by Patel, Indravadan H; Levy, René H; Wilensky, Alan J; Bowdle, T Andrew


Book ID
109842896
Publisher
Nature Publishing Group
Year
1980
Tongue
English
Weight
433 KB
Volume
28
Category
Article
ISSN
0009-9236

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The effects of three levels of salicylic acid on the steady-state plasma concentrations of free and total valproic acid were examined in catheterized rhesus monkeys. Valproate was infused intravenously for a total of 41 hr, and salicylate was added after the first 8 hr. The three salicylate infusion