Plasma protein binding interaction between valproic and salicylic acids in rhesus monkeys

✍ Scribed by C. T. Viswanathan; R. H. Levy

• Publisher: John Wiley and Sons
• Year: 1981
• Tongue: English
• Weight: 308 KB
• Volume: 70
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600701125

✦ Synopsis

The effects of three levels of salicylic acid on the steady-state plasma concentrations of free and total valproic acid were examined in catheterized rhesus monkeys. Valproate was infused intravenously for a total of 41 hr, and salicylate was added after the first 8 hr. The three salicylate infusions were randomly assigned to each monkey. Valproate free fraction was determined by equilibrium dialysis. Statistically significant increases in valproate free fraction and total body clearance were observed after addition of salicylic acid. The increase in valproate clearance was positively correlated with the molar ratio of salicylate to valproate steady-state plasma concentrations. There was no significant change in valproate free concentration after salicylate treatment. The proposed mechanism of this in uiuo interaction includes plasma protein binding displacement with no change in valproate intrinsic clearance.

Keyphrases Valproic acid-plasma protein binding interaction with salicylic acid, rhesus monkey D Salicylic acid-plasma protein binding with valproic acid, rhesus monkey 0 Plasma protein binding-interaction between valproic and salicylic acids, rhesus monkey