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Interaction between phenytoin and valproic acid: Plasma protein binding and metabolic effects

✍ Scribed by Perucca, E; Hebdige, S; Frigo, G M; Gatti, G; Lecchini, S; Crema, A


Book ID
109842940
Publisher
Nature Publishing Group
Year
1980
Tongue
English
Weight
731 KB
Volume
28
Category
Article
ISSN
0009-9236

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Plasma protein binding interaction betwe
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The effects of three levels of salicylic acid on the steady-state plasma concentrations of free and total valproic acid were examined in catheterized rhesus monkeys. Valproate was infused intravenously for a total of 41 hr, and salicylate was added after the first 8 hr. The three salicylate infusion