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Valproate increases cyclin-dependent kinase inhibitor 1a gene expression in the hippocampus of mice

โœ Scribed by Shu Aizawa; Kyoko Teramoto; Misato Suzuki; Satomi Yamaguchi; Yutaka Yamamuro

Book ID
116778897
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
106 KB
Volume
71
Category
Article
ISSN
0168-0102

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WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet