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Gene expression profiling of the cyclin-dependent kinase inhibitor CYC202 (R-Roscovitine)


Book ID
117659496
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
142 KB
Volume
38
Category
Article
ISSN
0959-8049

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## Abstract CDK2 inhibitors have been proposed as effective anti‐cancer therapeutics. We show here that CYC202 (__R__‐roscovitine) is a potent inhibitor of recombinant CDK2/cyclin E kinase activity (IC~50~ = 0.10 ΞΌM) with an average cytotoxic IC~50~ of 15.2 ΞΌM in a panel of 19 human tumour cell lin