In vitro and in vivo antitumor propertie
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Steven J. McClue; David Blake; Rosemary Clarke; Angela Cowan; Lorna Cummings; Pe
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Article
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2002
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John Wiley and Sons
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French
β 112 KB
## Abstract CDK2 inhibitors have been proposed as effective antiβcancer therapeutics. We show here that CYC202 (__R__βroscovitine) is a potent inhibitor of recombinant CDK2/cyclin E kinase activity (IC~50~ = 0.10 ΞΌM) with an average cytotoxic IC~50~ of 15.2 ΞΌM in a panel of 19 human tumour cell lin