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Validation of brain tumour imaging withp-[123I]iodo-l-phenylalanine and SPECT

✍ Scribed by Dirk Hellwig; Ralf Ketter; Bernd F. M. Romeike; Nadja Sell; Andrea Schaefer; Jean R. Moringlane; Carl-Martin Kirsch; Samuel Samnick


Publisher
Springer
Year
2005
Tongue
English
Weight
228 KB
Volume
32
Category
Article
ISSN
0340-6997

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Synthesis of L-6-[123I]iodo-m-tyrosine a
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## Abstract L‐6‐[^123^I]Iodo‐__m__‐tyrosine was synthesized by the direct iodination of L‐__m__‐tyrosine with [^123^I]‐NaI and Chloramine‐T. The product was purified by reverse phase HPLC to give the final product in 57% radiochemical yield with a radiochemical purity of greater than 97%.

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A bst rnct in buffer(pH 4) for 35 minutes at 97Β°C. The synthesis was complete in approximately 1 hour with a radiochemical yield of 50% , a specific activity of 65 Ci/mmol and a radiochemical purity of >95%. A non radioactive standard of L-6-iododopa was synthesized by the iododemercuration of a mer