Validation of brain tumour imaging withp-[123I]iodo-l-phenylalanine and SPECT
β Scribed by Dirk Hellwig; Ralf Ketter; Bernd F. M. Romeike; Nadja Sell; Andrea Schaefer; Jean R. Moringlane; Carl-Martin Kirsch; Samuel Samnick
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 228 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0340-6997
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## Abstract Lβ6β[^123^I]Iodoβ__m__βtyrosine was synthesized by the direct iodination of Lβ__m__βtyrosine with [^123^I]βNaI and ChloramineβT. The product was purified by reverse phase HPLC to give the final product in 57% radiochemical yield with a radiochemical purity of greater than 97%.
A bst rnct in buffer(pH 4) for 35 minutes at 97Β°C. The synthesis was complete in approximately 1 hour with a radiochemical yield of 50% , a specific activity of 65 Ci/mmol and a radiochemical purity of >95%. A non radioactive standard of L-6-iododopa was synthesized by the iododemercuration of a mer