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Validated LC–MS/MS method for the quantitative determination of the glucosylceramide synthase inhibitor miglustat in mouse plasma and human plasma and its application to a pharmacokinetic study

✍ Scribed by Elke Spieker; Winfried Wagner-Redeker; Jasper Dingemanse

Book ID
113743236
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
408 KB
Volume
59
Category
Article
ISSN
0731-7085

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✍ Satish R. Patil; Ketan K. Nerurkar; Ashok M. Kalamkar; Vishwas Pukale; Kiran V. 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 196 KB 👁 2 views

An analytical method based on liquid–liquid extraction has been developed and validated for analysis of agomelatine in human plasma. Fluoxetine was used as an internal standard for agomelatine. A Betasil C18 (4.0 × 100 mm, 5 µm) column provided chromatographic separation of analytes followed by dete