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Validated LC-MS/MS assay for the quantitative determination of nalbuphine in human plasma and its application to a pharmacokinetic study

✍ Scribed by Li-Jing Cai; Jun Zhang; Xiu-Mei Wang; R. H. Zhu; Jian Yang; Qi-Zhi Zhang; W. X. Peng

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
217 KB
Volume
25
Category
Article
ISSN
0269-3879

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Development and validation of a highly sensitive LC-MS/MS method for quantitation of dexlansoprazole in human plasma: application to a human pharmacokinetic study
✍ Kishore Kumar Hotha; D. Vijaya Bharathi; B. Jagadeesh; L. K. Ravindranath; K. N. πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 311 KB πŸ‘ 2 views

## ABSTRACT A highly sensitive, specific and simple LC‐MS/MS method was developed for the simultaneous estimation of dexlansoprazole (DEX) with 50 μL of human plasma using omeprazole as an internal standard (IS). The API‐4000 LC‐MS/MS was operated under multiple reaction‐monitoring mode using elect