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Validated LC-MS/MS assay for the quantitative determination of vardenafil in human plasma and its application to a pharmacokinetic study

✍ Scribed by Simon T. Lake; Phillip M. Altman; Jack Vaisman; Russell S. Addison


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
282 KB
Volume
24
Category
Article
ISSN
0269-3879

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## ABSTRACT A highly sensitive, specific and simple LC‐MS/MS method was developed for the simultaneous estimation of dexlansoprazole (DEX) with 50 μL of human plasma using omeprazole as an internal standard (IS). The API‐4000 LC‐MS/MS was operated under multiple reaction‐monitoring mode using elect