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Validated LC–MS (ESI) assay for the simultaneous determination of amitriptyline and its metabolite nortriptyline in rat plasma: Application to a pharmacokinetic comparison

✍ Scribed by Yuan Shen; Rong-Hua Zhu; Huan-De Li; Yan-Wen Liu; Ping Xu


Book ID
108189789
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
210 KB
Volume
53
Category
Article
ISSN
0731-7085

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✍ Kuldeep Sharma; Murugesh Kandaswamy; Chandan Mithra; Ashok Kumar Meena; Sanjeev 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 628 KB

## ABSTRACT A highly sensitive and specific LC‐MS/MS‐ESI method was developed for simultaneous quantification of albenadazole (ABZ) and ricobendazole (RBZ) in rat plasma (50 μL) using phenacetin as an internal standard (IS). Simple protein precipitation was used to extract ABZ and RBZ from rat plas