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Validated LC-MS method for simultaneous quantitation of catalpol and harpagide in rat plasma: application to a comparative pharmacokinetic study in normal and diabetic rats after oral administration of Zeng-Ye-Decoction

✍ Scribed by Feng, Yukun; Liu, Zhenzhen; Peng, Ying; Zhang, Lunhui; Ju, Ping; Bi, Kaishun; Chen, Xiaohui

Book ID
120483053
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
406 KB
Volume
27
Category
Article
ISSN
0269-3879

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## ABSTRACT A highly sensitive and specific LC‐MS/MS‐ESI method was developed for simultaneous quantification of albenadazole (ABZ) and ricobendazole (RBZ) in rat plasma (50 μL) using phenacetin as an internal standard (IS). Simple protein precipitation was used to extract ABZ and RBZ from rat plas