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An LC/MS/MS method for simultaneous quantitation of two homoisoflavones: Protosappanin B and brazilin with hypoglycemic activity in rat plasma and its application to a comparative pharmacokinetic study in normal and streptozotocin-treated rats

✍ Scribed by Tong, Xiao-Zhe; Zhu, Hui; Shi, Yan; Xu, Hai-Tao; Wang, Biao; Zhao, Jiu-Han

Book ID
121370608
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
886 KB
Volume
148
Category
Article
ISSN
0378-8741

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## ABSTRACT A highly sensitive and specific LC‐MS/MS‐ESI method was developed for simultaneous quantification of albenadazole (ABZ) and ricobendazole (RBZ) in rat plasma (50 μL) using phenacetin as an internal standard (IS). Simple protein precipitation was used to extract ABZ and RBZ from rat plas