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A validated LC-MS/MS method for rapid determination of brazilin in rat plasma and its application to a pharmacokinetic study

✍ Scribed by Deng, Zhipeng; Wang, Xin; Zhao, Huanxin; Cui, Shuxiang; Yao, Qingqiang; Bai, Hong

Book ID
118275859
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
389 KB
Volume
27
Category
Article
ISSN
0269-3879

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An analytical method based on liquid–liquid extraction has been developed and validated for analysis of agomelatine in human plasma. Fluoxetine was used as an internal standard for agomelatine. A Betasil C18 (4.0 × 100 mm, 5 ¡m) column provided chromatographic separation of analytes followed by dete