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Valdiation of Trypanosoma brucei trypanothione synthetase as drug target

✍ Scribed by Marcelo A Comini; Sergio A Guerrero; Simon Haile; Ulrich Menge; Heinrich Lünsdorf; Leopold Flohé

Book ID
113629108
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
834 KB
Volume
36
Category
Article
ISSN
0891-5849

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Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite __Trypanosoma brucei__, which causes human African trypanosomiasis. It is one of only a handful of chemically validated targets for __T. brucei__ in vivo. To identify novel inhibitors of __Tb__TryS we screened ou