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Properties of trypanothione synthetase from Trypanosoma brucei

✍ Scribed by Sandra L. Oza; Mark R. Ariyanayagam; Niall Aitcheson; Alan H. Fairlamb


Book ID
114146015
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
270 KB
Volume
131
Category
Article
ISSN
0166-6851

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Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite __Trypanosoma brucei__, which causes human African trypanosomiasis. It is one of only a handful of chemically validated targets for __T. brucei__ in vivo. To identify novel inhibitors of __Tb__TryS we screened ou