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Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

✍ Scribed by Daniel Spinks; Emma J. Shanks; Laura A. T. Cleghorn; Stuart McElroy; Deuan Jones; Daniel James; Alan H. Fairlamb; Julie A. Frearson; Paul G. Wyatt; Ian H. Gilbert


Book ID
102104994
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
366 KB
Volume
4
Category
Article
ISSN
1860-7179

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ChemInform Abstract: New Potent Inhibito
✍ S. GIRAULT; S. BAILLET; D. HORVATH; V. LUCAS; E. DAVIOUD-CHARVET; A. TARTAR; C. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 2 views

New Potent Inhibitors of Trypanothione Reductase from Trypanosoma cruzi in the 2-Aminodiphenylsulfide Series. -A series of compounds such as (I)-(III) are prepared to investigate their TR inhibition. Derivative (Ib) is revealed to be the best inhibitor described so far.