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UV-light induced sister chromatid exchanges in xeroderma pigmentosum lymphocytes

✍ Scribed by A. Dorothee Schönwald; E. Passarge

Publisher
Springer
Year
1977
Tongue
English
Weight
264 KB
Volume
36
Category
Article
ISSN
0340-6717

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✦ Synopsis

Cultured lymphocytes from 9 patients with clinically different types of xeroderma pigmentosum were exposed to ultraviolet light at 24 h. An increased rate of sister chromatid exchanges were observed in 6 patients (128--148% increase in three, 34--51% in three), but not in three patients with deSanctis-Cacchione syndrome (xeroderma pigmentosum with mental defect), compared to simultaneously cultured controls. A positive result could be useful as preliminary cytogenetic diagnostic test. The results are interpreted as an expression of UV-light induced chromosomal instability due to impaired DNA repair.

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