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Utilization of transgenic mice replicating high levels of hepatitis B virus for antiviral evaluation of lamivudine

โœ Scribed by John D. Morrey; Kevin W. Bailey; Brent E. Korba; Robert W. Sidwell

Book ID
114145209
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
226 KB
Volume
42
Category
Article
ISSN
0166-3542

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Transgenic mice replicating hepatitis B
Transgenic mice replicating hepatitis B virus but lacking expression of the major HBsAg
โœ Leonie Halverscheid; Nina K. Mannes; Robert Weth; Manuela Kleinschmidt; Ursula S ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 262 KB

## Abstract Hepatitis B Virus (HBV) transgenic mice replicating the viral genome at high level but lacking expression of the small envelope protein (HBsAg) have been produced using a terminally redundant viral DNA construct (HBV 1.4). The generation of viable infectious progeny was dependent on sex