Characterization of antiviral activity of entecavir in transgenic mice expressing hepatitis B virus
β Scribed by Justin G Julander; Richard J Colonno; Robert W Sidwell; John D Morrey
- Book ID
- 114144543
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 112 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0166-3542
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Aucubin, an iridoid glycoside was found to suppress hepatitis B virus DNA replication in vitro in a 2.2.15 cell culture system. Aucubin itself did not exhibit antiviral activity, but it showed significant activity when preincubated with β€-glucosidase. Aucubin possesses no cytotoxicity at a broad ran
## Abstract Hepatitis B Virus (HBV) transgenic mice replicating the viral genome at high level but lacking expression of the small envelope protein (HBsAg) have been produced using a terminally redundant viral DNA construct (HBV 1.4). The generation of viable infectious progeny was dependent on sex