Utilization of Sequential Palladium-Catalyzed Cross-Coupling Reactions in the Stereospecific Synthesis of Trisubstituted Olefins
✍ Scribed by Houpis, Ioannis N.; Schils, Didier; Nettekoven, Ulrike; Schnyder, Anita; Bappert, Erhart; Weerts, Koen; Canters, Martine; Vermeulen, Wim A. A.
- Book ID
- 126493677
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 28 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1083-6160
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📜 SIMILAR VOLUMES
A stereospecific synthesis of the drug-candidate 1 is described. The synthetic sequence, aimed at accomplishing modularity and cost savings, features a series of organometallic steps to afford stereospecifically the desired trisubstituded olefin active pharmaceutical ingredient. Key developments con
Differentially substituted indoiocarbazoles are readily prepared via a synthetic route employing two palladium catalyzed reactions. First, biindoles are prepared from a palladium catalyzed cross coupling reaction. Second, a new palladium catalyzed benzannulation reaction employing biindolyl iodides