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Stereoselective Synthesis of Functionalized Trisubstituted Olefins via Palladium(0)-Catalyzed Cross-Coupling Reaction

โœ Scribed by Arefolov, Alexander; Langille, Neil F.; Panek, James S.


Book ID
123612587
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
61 KB
Volume
3
Category
Article
ISSN
1523-7060

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A stereospecific synthesis of the drug-candidate 1 is described. The synthetic sequence, aimed at accomplishing modularity and cost savings, features a series of organometallic steps to afford stereospecifically the desired trisubstituded olefin active pharmaceutical ingredient. Key developments con