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Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. An efficient solid-phase synthesis of olomoucine

✍ Scribed by Lars G.J Hammarström; David B Smith; Francisco X Talamás; Sharada S Labadie; Nancy E Krauss

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 232 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)01953-6

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✦ Synopsis

Dichloro-2-(methylthio)-5-nitropyrimidine has been utilized as a building block for an efficient nine-step synthesis of olomoucine. The methodology reported herein is applicable to the regiocontrolled solution and solid-phase synthesis of libraries of highly substituted purines, as well as other related scaffolds.

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