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An efficient solid-phase synthesis of 3-alkylamino-1,2,4-oxadiazoles

✍ Scribed by Gergely M Makara; Peter Schell; Kelley Hanson; Dennis Moccia

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
95 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

A solid-phase synthesis of substituted 3-alkylamino-1,2,4-oxadiazoles has been developed. The synthesis utilizes immobilized N-acyl-1H-benzotriazole-1-carboximidamides as key intermediates. Cyclization with hydroxylamine under mild conditions furnished the oxadiazole skeleton regioselectively in high yield and purity.

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