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An efficient synthesis of pharmacologically active derivatives of 1,3,4-oxadiazoles

✍ Scribed by Ravindra R. Kamble; Belagur S. Sudha

Publisher: Journal of Heterocyclic Chemistry
Year: 2006
Tongue: English
Weight: 126 KB
Volume: 43
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570430214

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✦ Synopsis

A simple and environmental friendly microwave irradiation method is devised for the synthesis of derivatives of 1,3,4-oxadiazoles viz., 6a-e and 7h-q in 75-90% yield. Structures of the newly synthesised compounds were confirmed by physical, analytical and spectral (ir, 1 H and 13 C nmr and ms) data and screened for antiinflammatory, anticonvulsant, antidiuretic and antihaemostatic activities. Some of the compounds have shown potent activities.

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