𝔖 Bobbio Scriptorium
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Using yeast models to probe the molecular basis of amyotrophic lateral sclerosis

✍ Scribed by Bastow, Emma L.; Gourlay, Campbell W.; Tuite, Mick F.

Book ID
120233960
Publisher
Portland Press
Year
2011
Tongue
English
Weight
251 KB
Volume
39
Category
Article
ISSN
0300-5127

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The discovery of mutations in the human SOD1 gene encoding Cu,Zn superoxide dismutase (Cu,Zn SOD) in patients with familial amyotrophic lateral sclerosis (ALS) has made possible the development of etiological models of the disease. Expression of mutant SOD1 genes in transgenic mice causes a progress