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Altered reaction of facial motoneurons to axonal damage in the presymptomatic phase of a murine model of familial amyotrophic lateral sclerosis

✍ Scribed by R Mariotti; L Cristino; C Bressan; S Boscolo; M Bentivoglio

Book ID
117490740
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
326 KB
Volume
115
Category
Article
ISSN
0306-4522

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## Abstract Microglial activation occurs early during the pathogenesis of amyotrophic lateral sclerosis (ALS). Recent evidence indicates that the expression of mutant Cu^2+^/Zn^2+^ superoxide dismutase 1 (SOD1) in microglia contributes to the late disease progression of ALS. However, the mechanism