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Usefulness of Indomethacin for Patent Ductus Arteriosus in Full-Term Infants

โœ Scribed by Takeshi Takami; Hitoshi Yoda; Tadashi Kawakami; Hideshi Yamamura; Toshio Nakanishi; Makoto Nakazawa; Yukito Takei; Tasuku Miyajima; Akinori Hoshika

Publisher
Springer
Year
2007
Tongue
English
Weight
54 KB
Volume
28
Category
Article
ISSN
0172-0643

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Indomethacin and cerebral blood flow in
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Central blood flow (CBF) was estimated by an intravenous 133-xenon technique in six preterm infants before and after administration of indomethacin for closure of patent ductus arteriosus. CBF fell in all infants (range 12%-40%), the mean fall was 24% (P less than 0.005). Though none of the infants

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Sixteen premature infants were treated with indomethacin, either orally or intravenously, in order to close a symptomatic patent ductus arteriosus requiring mechanical ventilation. Positive effect was obtained in 4 of the 10 orally treated patients and in 1 of the 6 with intravenous administration.