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Indomethacin and cerebral blood flow in premature infants treated for patent ductus arteriosus

✍ Scribed by O. Pryds; G. Greisen; K. H. Johansen


Publisher
Springer
Year
1988
Tongue
English
Weight
172 KB
Volume
147
Category
Article
ISSN
0340-6997

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✦ Synopsis


Central blood flow (CBF) was estimated by an intravenous 133-xenon technique in six preterm infants before and after administration of indomethacin for closure of patent ductus arteriosus. CBF fell in all infants (range 12%-40%), the mean fall was 24% (P less than 0.005). Though none of the infants showed signs of impaired cerebral function during or following the injections, the results do not indicate whether or not the use of indomethacin is a potential hazard.


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Sixteen premature infants were treated with indomethacin, either orally or intravenously, in order to close a symptomatic patent ductus arteriosus requiring mechanical ventilation. Positive effect was obtained in 4 of the 10 orally treated patients and in 1 of the 6 with intravenous administration.