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Effectiveness and pharmacokinetics of indomethacin in premature newborns with patent ductus arteriosus

โœ Scribed by P. Vert; G. Bianchetti; F. Marchal; P. Monin; P. L. Morselli


Publisher
Springer
Year
1980
Tongue
English
Weight
474 KB
Volume
18
Category
Article
ISSN
0031-6970

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Sixteen premature infants were treated with indomethacin, either orally or intravenously, in order to close a symptomatic patent ductus arteriosus requiring mechanical ventilation. Positive effect was obtained in 4 of the 10 orally treated patients and in 1 of the 6 with intravenous administration.

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Central blood flow (CBF) was estimated by an intravenous 133-xenon technique in six preterm infants before and after administration of indomethacin for closure of patent ductus arteriosus. CBF fell in all infants (range 12%-40%), the mean fall was 24% (P less than 0.005). Though none of the infants