Use of the non-aldol aldol process in the synthesis of the C1–C11 fragment of the tedanolides: use of lactol ethers in place of tetrahydrofurans

✍ Scribed by Michael E Jung; Christopher P Lee

• Book ID: 104211273
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 107 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01726-3

✦ Synopsis

The use of a lactol methyl ether 23 in place of the simple tetrahydrofuran 11 allows for the high yielding non-aldol aldol process to occur without concomitant tetrahydropyran formation (cf. 13) to give the desired product 24 in good yield.