Use of the hypoxic cell sensitizer etanidazole (SR-2508) with intravenous melphalan and prednisone in the treatment of multiple myeloma: A pharmacokinetic study
β Scribed by Lawrence N. Shulman; Lori Buswell; Leslie A. Kalish; C. Norman Coleman
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 422 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0360-3016
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## Abstract A study was designed to evaluate the effectiveness of prednisone therapy in poorβrisk patients with multiple myeloma. Patients were treated with melphalan alone or in combination with prednisone at doses of either 0.6 mg/kg or 0.3 mg/ kg. The group of patients receiving melphalan and pr
## METHODS. Four hundred seventy-nine previously untreated patients with multiple myeloma from 23 ECOG institutions were enrolled. Treatment, assigned by ran-1 The Virginia Piper Cancer Institute and the Unidomization, consisted of either 4-week cycles of MP or 5-week cycles of VBCMP.