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The treatment of multiple myeloma using vincristine, carmustine, melphalan, cyclophosphamide, and prednisone (VBMCP) alternating with high-dose cyclophosphamide and α2β interferon versus VBMCP : Results of a phase III Eastern Cooperative Oncology Group Study E5A93

✍ Scribed by Robert A. Kyle; Susanna Jacobus; William R. Friedenberg; Coenraad Frederik Slabber; S. Vincent Rajkumar; Philip R. Greipp

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
341 KB
Volume
115
Category
Article
ISSN
0008-543X

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## METHODS. Four hundred seventy-nine previously untreated patients with multiple myeloma from 23 ECOG institutions were enrolled. Treatment, assigned by ran-1 The Virginia Piper Cancer Institute and the Unidomization, consisted of either 4-week cycles of MP or 5-week cycles of VBCMP.

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## BACKGROUND. Interferon (IFN) has demonstrated activity in the treatment of patients with multiple myeloma. A previous Eastern Cooperative Oncology Group (ECOG) study suggested that the rates of complete response (CR) and survival were increased with a regimen that alternated IFN with chemothera