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Comparison of oral melphalan, CCNU, and BCNU with and without vincristine and prednisone in the treatment of multiple myeloma. Cancer and leukemia group B experience

✍ Scribed by Gibbons G. Cornwell III; Thomas F. Pajak; Shaul Kochwa; O. Ross McIntyre; Linda P. Glowienka; Kurt Brunner; Sameer Rafla; Richard T. Silver; M. Robert Cooper; Edward Henderson; Robert A. Kyle; Farid I. Haurani; Janet Cuttner

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
586 KB
Volume
50
Category
Article
ISSN
0008-543X

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## METHODS. Four hundred seventy-nine previously untreated patients with multiple myeloma from 23 ECOG institutions were enrolled. Treatment, assigned by ran-1 The Virginia Piper Cancer Institute and the Unidomization, consisted of either 4-week cycles of MP or 5-week cycles of VBCMP.

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## Abstract A study was designed to evaluate the effectiveness of prednisone therapy in poor‐risk patients with multiple myeloma. Patients were treated with melphalan alone or in combination with prednisone at doses of either 0.6 mg/kg or 0.3 mg/ kg. The group of patients receiving melphalan and pr