✦ LIBER ✦

Use of serotype-specific monoclonal antibodies to study the epidemiology of rotavirus infection

✍ Scribed by Dr. C. J. Birch; R. L. Heath; I. D. Gust

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 646 KB
Volume: 24
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890240107

No coin nor oath required. For personal study only.

✦ Synopsis

The development of an enzyme immunoassay (EIA) capable of serotyping human rotavirus (HRV) in faecal extracts has enabled us to retrospectively study the epidemiology of rotavirus infection in Melbourne. Of 552 stored specimens obtained from individuals with rotavirus-associated gastroenteritis between 1975 and 1986, the serotype could be determined in 62%. Infection was most prevalent in two groups, neonates and children aged between 12 and 24 months. In these groups infection was due to different serotypes, type 1 in older children and an untypable virus in infants. Serotype 1 strains were detected in greater numbers than the other serotypes and circulated in each year of the study. Serotype 2 rotaviruses were associated with a large epidemic in 1978, but have been detected only rarely since.

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