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Use of plasma mevalonate to monitor HMG CoA reductase inhibition

โœ Scribed by G.R. Thompson; V. Maher; A. Pappu; D.R. Illingworth


Book ID
118896185
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
127 KB
Volume
79
Category
Article
ISSN
0021-9150

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## Abstract The cholesterolโ€lowering drug simvastatin (SIMV, Zocor^ยฎ^) reduced heart attacks by 42% in patients who had high cholesterol levels and suffered from heart disease. Upon oral administration, SIMV is quickly hydrolyzed to its ฮฒโ€hydroxyacid and other acid metabolites, which are potent inh