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Optimization of a heterologous mevalonate pathway through the use of variant HMG-CoA reductases

✍ Scribed by Suzanne M. Ma; David E. Garcia; Alyssa M. Redding-Johanson; Gregory D. Friedland; Rossana Chan; Tanveer S. Batth; John R. Haliburton; Dylan Chivian; Jay D. Keasling; Christopher J. Petzold; Taek Soon Lee; Swapnil R. Chhabra


Book ID
113964200
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
760 KB
Volume
13
Category
Article
ISSN
1096-7176

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## Abstract HMG‐CoA reductase catalyzes the synthesis of mevalonate, a crucial intermediate in the biosynthesis of cholesterol and non‐sterol isoprenoid compounds essential for cell growth. The HMG‐CoA reductase activity of the A549 tumor cell line is higher than that of normal human fibroblasts. T