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Automated enzyme inhibition assay method for the determination of atorvastatin-derived HMG-CoA reductase inhibitors in human plasma using radioactivity detection

✍ Scribed by Robert J. Valesky; Lida Liu; Donald G. Musson; Jamie J. Zhao


Book ID
113941390
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
799 KB
Volume
57
Category
Article
ISSN
1056-8719

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## Abstract The cholesterol‐lowering drug simvastatin (SIMV, Zocor^®^) reduced heart attacks by 42% in patients who had high cholesterol levels and suffered from heart disease. Upon oral administration, SIMV is quickly hydrolyzed to its β‐hydroxyacid and other acid metabolites, which are potent inh