Use of partition coefficients in flow-limited physiologically-based pharmacokinetic modeling
β Scribed by Matthew D. Thompson, Daniel A. Beard, Fan Wu
- Book ID
- 113072091
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 741 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1573-8744
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π SIMILAR VOLUMES
## Abstract A physiologically based pharmacokinetic (PBPK) model for simulating the kinetics of cyclotrimethylene trinitramine (RDX) in male rats was developed. The model consisted of five compartments interconnected by systemic circulation. The tissue uptake of RDX was described as a perfusionβlim
The tissue:plasma (P t:p ) partition coefficients (PCs) are important drugspecific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. Until now the use of PBPK models in early stages of the drug discovery process was not possib